Exact(2)
This is of particular concern when considering problematic pathogens such as those producing extended-spectrum beta-lactamases, or P. aeruginosa and Acinetobacter spp., which may have high cefepime MICs (≥8 mg/l) and pose major therapeutic challenges, and if one takes into account that up to 20% of the total drug is bound to serum proteins [ 47, 48].
Criteria for considering problematic clones were: 1) clones with absolute value of log2 ratios > 0.2 in self-self hybridizations, 2) clones with high standard deviations (SD) (> 2 times the deviation of deviations) in different hybridizations and 3) clones displaying normal log2 ratios within a known aberration.
Similar(57)
Russia will have an optional on-ice session that the union does not consider problematic.
Both approaches are considered problematic and potentially explosive by peace advocates.
Over-recruitment and English language monitoring were considered problematic this year, for example (pdf).
The 1,600 units in East Jerusalem constituted the latest of several steps that the Americans considered problematic.
Last year, the women had been prompted to list their five favorite books, or other pieces of "intellectual media," which many of the women considered problematic.
On the other hand, regardless of the healthiness of Subway's offerings, they are still being directly marketed to children, a strategy many parents consider problematic.
It is a neighborhood that even five years ago was considered problematic for residential development, primarily because the sprawling Cabrini-Green public housing project is across the street.
The military also said that Palestinian medical officials had not immediately provided the military with the medical reports, a lack of cooperation that the military considered problematic.
The first, sent by Omar to Zahid, warned that "difficult times may lie ahead" for his family and to "get rid of any material you may consider problematic".
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