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Signal transduction seems to be impaired in the deletion strain considering its inability to induce genes in the "second messenger mediated signal transduction" category, in opposition to the wild-type.
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There was greater willingness to consider its use for secondary prevention, but with the same provisos about wanting to continue monitoring and with concerns about the inability to adjust the dose.
But consider its provenance.
Consider its weight.
Consider its end life.
Consider its color.
As a postscript, I have a Keanu theory that may go a little way to ease the guiltiness of the pleasure for viewers of The Lake House: considering his inability to keep the truth of his essential self from the screen, might there not be something of the Cassavetes ideal at work here: an authenticity to his on-screen behaviour that is more real than most slick, Hollywood acting?
But despite the appearance of prosperity, the government of Mammoth Lakes is considering bankruptcy because of its inability to pay a $43 million legal judgment in a development dispute dating back to 1997.
He alleged the Spanish firm was considering winding down due to its inability to shift its devices, something Silent Circle was unaware of when they combined forces.
Considering their inability to receive criticism, perfectionists sure can dish it out.
With so many factors possibly contributing to graft failure, and considering our inability to precisely measure the various contributing factors, we argue it is difficult or impossible to critically assess a new immunosuppressive regimen in the islet transplant recipient.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com