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When considering enriched themes found in all four platforms, there were 15 GO terms from the "biological process" category enriched in MRP1 compared to MRP2 and 12 GO terms from the "molecular function" category.
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Elements were considered enriched if they displayed an enrichment of at least a ±1.5 fold change and had a P-value < = 0.05.
Functional categories were considered enriched when the –log scale geometric mean p-value ≤ 0.05 (enrichment score ≥ 1.3).
Terms with P values adjusted for multiple testing ≤ 0.01 were considered enriched.
The second reason is that our mice are routinely kept in conditions that would, in most labs, be considered "enriched" already.
Functional annotation terms were considered enriched for an Enrichment Score larger than 3, which corresponds to a geometric average p-value of 0.001.
Genes were ranked by fold change calculated using the "difference of class means" metric implemented in the GSEA software, such that genes ranked towards the top of the list are considered enriched in one sample group and genes ranked at the bottom are considered enriched in the other.
Reactome pathways exhibiting FDR values < 0.01 were considered enriched.
Only the pathways with corrected P values less than 0.05 were considered enriched.
All processes (Biological Processes, Molecular Function, Cellular Component) considered enriched in each time period are shown.
GO terms were considered enriched for a modifided Fisher Exact p-value (EASE score) < 0.05.
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