Also of potential significance in considering the downstream effects of ApoE levels is that the cholinergic pathway is highly dependent upon lipid homeostasis for the synthesis of acetylcholine [ 40].
This result supports our initial conclusion that considering the downstream effect of miRNA on protein partners of target is useful and has prognostic value.
Three case studies were presented at the workshop that described available data on toxicologic pathways connecting chemical exposures to early upstream biological events and then to subsequent overt effects, which are considered "downstream": a) thyroid hormone disruption and related toxicities; b) antiandrogen-mediated male reproductive effects; and c) upstream indicators of immunosuppression.
5 Yet, tissue damage associated with IBD is commonly considered solely a downstream effect and not a contributing factor.
In patients with unilateral renovascular FMD, activation of renin angiotensin aldosterone system (RAAS) with its downstream effects is considered the primary mechanism of hypertension.
While an immediate benefit related to pain scores and immune marker levels may not have been observed, combined treatment, particularly as an adjunct therapy that extends beyond the period of antibiotic dosing, is likely to still yield significant benefits for the patient when the downstream effects are considered, compared to antibiotic treatment alone.
Can the association between upstream events and downstream effects for chemicals considered in the case study be generalized to other chemicals that have the same upstream effects?
Instead, the court remanded for BLM to "strengthen" its discussion of downstream effects and directed the agency to consider whether quantifying greenhouse gas emissions from downstream use was "reasonably possible," including through use of an emissions calculator suggested by the plaintiffs.
Even in this hypothesis, the inflammatory reaction is still considered to be a downstream effect of the accumulated proteins (amyloid beta (Aβ) and tau).
"It's like a cascade of related downstream effects, and all of them have to be considered," she told me at the end of a long September day.
But what I think is often ignored is that there are downstream effects.
