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They simply compute the indicator of intensity of change for each type of tools as the first difference between these two composite indicators.7 We discretize these indicators by considering as substantial changes that exceed about one standard deviation8 of their distribution.
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PNO was considered as substantial if drainage was needed.
An I value >50% was considered as substantial heterogeneity.
A value >50% is considered as substantial heterogeneity.
Both kappa coefficients were considered as substantial agreement between the observers.
A Cohen's kappa coefficient >0.6 was considered as substantial agreement.
For this review a value greater than 50% was considered as substantial heterogeneity[ 22].
Criterion-related and concurrent validity were also in the range considered as substantial [ 30].
For burden (6 point scale) and overall QOL (7 point scale), a one point difference is considered as substantial.
For normal tissues the kappa coefficients were 0.693 for LSD1, 0.628 for HDAC2 and 0.605 for SIRT1, which were all considered as substantial agreement as well.
For staining of HDAC2 in tumor tissues, the kappa for scoring of the tumor tissue was not considered as substantial agreement.
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