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Methodological issues should always be considered with studies reporting low prevalence.
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Some potential confounding factors should be considered with observational studies such as the present case control investigation (Cole and Morrison, 1980).
Where sensitivity analysis was not possible due to lack of appropriate, robust literature, agreement on prognostic value was considered with other studies on OAC.
Thus, any interpretation of time-dependent variables (i.e. marital, employment, smoking, and drinking status) should be considered with caution; future studies utilizing a prospective design are needed.
Unfortunately this was not possible with the database currently available but would be considered with subsequent follow-up studies.
Additional cautions should be paid when the results are considered with reference in future studies.
Another caveat that needs to be considered with regard to our studies in swine concerns the experimental protocol used.
These results, when considered with those of previous studies, suggest that the PAC should not be routinely used for the management of acute lung injury.
When the results of the studies were considered with regard to statistical significance, the p value was less than 0.05.
Combining the available data, the recommendation is that all LS gene carriers should consider regular daily aspirin starting with their regular surveillance and that, when available, they should consider helping with studies to determine the optimal dose.
We considered studies with less than 100 participants small, studies with between 101 to 200 participants medium and studies with more than 201 participants large.
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