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The country-based strata considered were as follows: Australia, United Kingdom, Germany, USA, and all other countries (with smaller individual sample sizes) pooled.
The distributed lag effects considered were as follows: For the moving average and distributed lag effects, five θ values corresponding to 0.25, 0.5, 1, 2, and 4% increases in mortality for each 10-μg/m increment in PM were used.
The areas considered were as follows: hyperlipidaemia : where there are both new and existing statins, plus other new drugs for reducing lipid levels (e.g. ezetmibe); diabetes : where there are new insulin analogues and long-acting insulin; rheumatoid arthritis : where there are several new biologic agents; schizophrenia : where there are several new atypical neuroleptics.
The life course socioeconomic position models considered were as follows: (1) sensitive periods in either childhood, early adulthood or middle age; (2) accumulation of risk of low social class in childhood and early adulthood, in adulthood only, and across all three time points; and (3) upward or downward social mobility in adulthood only and social mobility between any of the three time points.
The effects considered were as follows: assumption that those patients with unspecified influenza type A had pandemic (H1N1) 2009, no exclusion of patients if >4 days had elapsed between symptom onset and specimen collection, and no exclusion of patients if they were identified outside the defined influenza season.
The life course models considered were as follows: (1) an accumulation model where only the duration of high BMI is allowed to explain knee OA (duration); (2) an accumulation model that is similar to (1) but additionally allows the effect of high BMI to vary by age of exposure (duration and age); and (3) period models where each period is separately allowed to explain knee OA risk.
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The transmission protocol considered is as follows.
The receivers considered are as follows.
The intervention measures considered are as follows.
For amyloid imaging studies, the contributions to consider are as follows.
The model we consider is as follows.
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