But the ability to observe the process is essential: "It is not enough to say that results alone will satiate the natural community desire for 'satisfaction.' A result considered untoward may undermine public confidence, and where the trial has been concealed from public view, an unexpected outcome can cause a reaction that the system, at best, has failed, and, at worst, has been corrupted".
It's considered unseemly, untoward, to be so desperate for attention.
Why were such gestures always considered sexual, one hand doing something untoward to the other hand?
However, contrary opinions were published by Venugopalan et al. [6] and Pollard [14], where stringent preoperative aseptic precautions were considered enough [6] and no untoward effects without antibiotic prophylaxis was demonstrated even in neonatal acute dacryocystitis [14].
Only untoward medical occurrences that are considered to be either possibly, probably or definitely related to the trial drug will be reported as having a causal relationship.
An untoward medical occurrence will be considered to be 'unexpected' if its nature and severity are not consistent with the information in the summary of product characteristics for that treatment.
If the untoward medical occurrence is not considered to have a causal relationship with the treatment at the time of the event (i.e. it is not believed to be a consequence of taking folic acid or placebo) this will be classified as an Adverse Event.
Patient-reported outcome of adverse event (PRO-AE): A PRO-AE is any untoward medical occurrence, whether or not considered treatment/intervention related, which is reported or transmitted directly by the patient without interpretation by a clinician or anyone else.
A recommended definition for PRO-AEs based on these resources, and used in this document, is as follows: A PRO-AE is any untoward medical occurrence, whether or not considered treatment/intervention related, that is reported or transmitted directly by the patient without interpretation by a clinician or anyone else.
The presence of any untoward event after endoscopic treatment was considered a complication such as gastrointestinal tract perforation or bleeding with clinical signs of hematemesis, coffee-ground vomitus, hematochezia, or melena, or significant pain requiring hospitalization, was defined as major complications.
Regarding to the possible complications of a prolonged intestinal atony (translocation, ileus operation, endotoxine transmission) and after trying all conservative efforts spinal sympathicolysis can he considered as an acceptable approach in spite of the possible untoward effects.
