Considering unaltered levels of home cage activity (Additional file 3c), this effect does not appear to reflect general hypolocomotion of LAMP-2-deficient mice.
Given the extremely high homogeneity of the soil profile and the similarity between the unaltered basalt and the deepest (C) soil horizon [42,45,47,49,52], the mineral soil horizon sampled below the rooting depth, 60 100 cm at the South-facing slope, can be considered as unaltered mineral substrate.
In more details, let us define with probability of false alarm (Pfa) the probability of detecting the repeated blocks as affected by errors in the absence of distortion and with probability of miss detection (Pmd) the probability of considering as unaltered a frame in the presence of errors.
Minimal HE was considered in patients with unaltered neurological status but with alterations in spectral analysis of EEG (i.e. grade ≥ 1 according to the system proposed by Amodio P. et al).
Although VSF is not a direct biomarker of therapy response, this parameter could be considered as an index of unaltered vasculature within the limit of the experimental measure method.
However, the relationship between network degree and all metrics of positive selection (2Δ ℓ and ZF) and purifying selection (ω and DAF) considered in this study remains unaltered when controlling for these parameters (table 1 and supplementary note and fig. S5, Supplementary Material online).
This reasoning would explain the difference in IL-6 levels between patients with AD and patients with DLB in our study, as the patients with DLB showed unaltered P-tau concentrations (considered to be indicative of few or no NFT), whereas the P-tau levels in the patients with AD were significantly elevated (considered to be indicative of NFT presence).
In the case that bone density remains unaltered, stable disease should be considered.
However, our results suggest that, whatever the fishing intensity considered, genetic diversity (expected heterozygosity) remains almost unaltered by genetic drift in large exploited marine fish populations, as expected from the range of Ne values observed in our model (Wright 1931).
As explanations for the elevated pri-miR-221/222 levels present in AML, pathologically increased transcription on the background of a physiologically limited processing capacity, or an acquired processing deficiency on the background of unaltered transcriptional activity may be considered.
