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The suboccipital dissection can be omitted if the risk of morbidity is considered to exceed the potential benefit.
Soon after 2000 when physician supply was considered to exceed demand [ 21], physician shortages emerged in the United States and Canada [ 4].
Two patients developed a DLT (grade 3 ALT elevation and grade 3 hypertension) at 400 mg day−1, which was considered to exceed the MTD.
Below this value, the cost of implementation is considered to exceed the extent of the savings, such costs being typically associated with activities such as the revision of guidelines, training of personnel and amendments to tendering procedures.
For patients in whom abdominal circumference was not measured, based on the relationship between abdominal circumference and BMI [ 26], those with BMI > 25 kg/m2 were considered to exceed the abdominal circumference threshold for MetS.
To determine the smallest change in each impairment measure that can confidently be considered to exceed measurement error at a 95% confidence level, the Minimum Detectable Change (MDC) was calculated according to the following formula [ 22]: MDC = 1.96 · √2 · SD · √(1 − test retest reliability coefficient).
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Since the ethanol concentration required for distillation is generally considered to have to exceed 4% for second generation biorefining, the substrate concentration of pretreated duckweed for SSF would have to be at least 20% (w/v) biomass since it is 35.2% glucose (Zhao et al., 2015).
In that time the United States has undoubtedly surpassed one of the so-called "birthplaces" of the sport at the international level, and may now be considered to have exceeded its Caledonian counterparts at the domestic level as well.
Therefore, tremelimumab 15 mg kg−1 plus PF-3512676 0.05 mg kg−1 was considered to have exceeded the MTD.
However, if two or more of three to six patients experienced a DLT during the first 6 weeks, the current dose level was considered to have exceeded the MTD, and dose escalation was discontinued.
If two or more patients at any dose level experienced DLT, then that dose level was considered to have exceeded the maximum tolerated dose (MTD), and the dose level immediately preceding that was designated as the MTD (equivalent to the recommended phase II dose).
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