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Although the responsible compounds are unknown, naphthenic acids (NAs) have been considered to be implicated.
Oxidative stress is considered to be implicated in the pathophysiology of polycystic ovary syndrome (PCOS).
ACC has a close interconnection with the insula, thalamus, prefrontal cortex, and other subcortical structures, and is considered to be implicated in both affective and cognitive-attentional dimensions of pain and plays a deterministic role in pain modulation and analgesia [37].
MMP activity has been considered to be implicated in collagen gel contraction and tissue reorganization as well [59], [60], [61].
Chronic inflammation is considered to be implicated in the development of prostate cancer.
For example, tobacco smoke is considered to be implicated in the pathogenesis of oral melanomas.
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Skin permeability is widely considered to be mechanistically implicated in chemically-induced skin sensitization.
In particular, ECM fragments and their receptors exhibit important effects on inflammatory cells and therefore are considered to be clearly implicated in the evolution of the immune interstitial response [ 16, 45, 80].
Thus, these prefibrillar oligomers are considered to be toxic and are implicated in β-cell dysfunction and death.
Cytokines and chemokines are considered to be immunological markers and have been implicated in endothelial dysfunction and subsequent vascular abnormalities (30).
Recently, multiple organs not traditionally considered to be regulators of metabolism have been implicated in the regulation of whole-body energy expenditure including the heart and the skeletal muscle [78,88,89].
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