Considering the expression pattern of ND chondrocytes, hierarchical clustering resulted in two main groups, classified as ML and scaffold.
These results supported, at least partly our findings that nuclear expression of HO-1 might be essentially correlated with the malignancy of CRC, and strongly suggested that it is critically important to consider the expression pattern of HO-1 in tumor cells when evaluating the roles of HO-1 in tumors.
Interestingly, the mouse gene B4galnt2 (encoding glycosyltransferase β-1,4-N-acetylgalactosaminyltransferase 2) has similar function in terms of determining the sugar composition of the intestinal mucosa, and it is tissue-specific when we consider the expression patterns.
In the first iteration, we examined the hypergeometric enrichment obtained when considering the expression patterns of the targets of only the first miR-seed.
In the second iteration, we examined the hypergeometric enrichment obtained when considering the expression patterns of the targets of the first and second miR-seeds, and so on.
However, most similarity measurement techniques including Pearson correlation usually consider the expression patterns between two genes under the same conditions or at the same time points, no time-lagging analysis is taken into account.
Finally, cluster 1 included many homologs of A. thaliana SPL genes (SPL2, SPL3, SPL4, SPL5, SPL8 and SPL9) what will be discussed later when considering the expression patterns observed within this gene family.
Considering the expression patterns of both transcription factors and mature-related genes, we infer that less rainfall and stronger sunshine in the GT region could initiate the earlier expression of ripening-related genes and accelerate the berry maturation, eventually limiting the production of terpene volatiles.
Six miRNAs showed a low variable pattern of expression (miR-29b, miR-29c, miR-19b, miR-31, miR-148a, miR-451) and could be considered part of the expression pattern of the healthy gastric tissue.
In other words, our module construction strategy considered the global expression pattern but ignored the local ones.
