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The inverse relationship initially observed in our PK PD analysis (for both CML and GIST patients) between Dose/AUC and therapeutic response could be considered paradoxical.
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He was especially troubled by what he considered the paradoxical teaching of the divinity of Wallace D. Fard, the founder of the Nation of Islam.
Until recently, inorganic arsenic was considered a "paradoxical" human carcinogen because of strong human evidence but limited evidence for animal carcinogenesis (IARC 1987; Waalkes et al. 2004a, 2004b).
Tracy Franz's "My Year of Dirt and Water" considers the paradoxical experience of being married to a Buddhist monk, cloistered in a Japanese temple.
But consider one paradoxical thing about Clark: "I know how it feels to be stuck in the hospital, away from your team, away from your family," he said.
"Sometimes we consider a paradoxical intervention and say to a patient, 'I really admire your loyalty to your parents — even at the expense of failing to protect yourself in any way from harm,' " Dr. Herman told me in an interview.
Considering this paradoxical reality, both Israelis and Palestinians have shown that they are simply incapable of resolving this conflict on their own.
Yet, given the challenges that precision medicine faces for correct design and interpretation of its research (indeed, consider the paradoxical findings that can only be tackled by proper understanding of molecular pathological epidemiology and other epidemiological concepts), I would expect the epidemiologist to be at the fore-front of precision medicine.
We considered this a paradoxical reaction similar to other reports in tuberculosis patients who had discontinued biological agent treatments, and increased the dose of oral glucocorticoids.
Reactivity to this serovar in the MAT has been considered a possible paradoxical cross-reaction with serovar Pomona (11 ); a strong positive correlation in titers for these 2 serovars was found in this study.
We considered this a paradoxical reaction similar to that noted in previous reports in patients with tuberculosis who discontinued biological agent therapy; therefore, we increased the PSL dosage to 10 mg/day.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com