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Results for all chromosomes of considered organisms are present on page Statistics of the HeteroGenome database (http://www.jcbi.ru/lp_baze/).ru/lp_baze/
We noticed that some of the motifs are unique in the considered organisms as reported in the literature [ 42].
Exploring the whole set of sequences is also an interesting strategy to analyse the evolution of the considered organisms.
The high connectivity as well as the nature of the partners those domains appear with indicate a central topological and functional role in the proteome of the considered organisms.
Phylogenetic analysis of the EFL sequences detected in this study gives a tree that is overall similar to other published EFL phylogenies (for example [ 13, 14, 16, 20]), although with fewer taxa as we only considered organisms with large scale EST and whole genome data available (Additional file 2: Figure S1A).
For a KOG to present maximal diversity their components are present in all species, meaning that this KOG ancestral gene arrived early in evolution, in the last common ancestor of all considered organisms - in our case, in the origin of eukaryotes or before.
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A weighted graph of domain co-occurrence was constructed for each considered organism.
In the past decade, however, research in very different areas has revealed a number of mechanisms in which noise actually proves beneficial for the considered organism.
The method used in our study is "observational" and because we know that all detected transcripts were indeed expressed, we know they constitute functional transcription units of the considered organism.
Remarkably, most of these values are ranging between 1 to 10 μM methylmercury whatever the considered organism, from bacteria to man, and for different cell types.
Here we focus on the comparative analysis of metagenomic sequencing data: we investigate how well different technologies represent information related to a considered organism of interest, and whether it is beneficial to combine information obtained using different technologies.
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