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In these studies, researchers considered only possible and proven IA, however.
Previously, a definite diagnosis of Alzheimer's disease was considered only possible by post-mortem histopathological analysis of the brain; however, the development of new biomarkers including the amyloid positron emission tomography (PET) tracer Pittsburgh Compound B (C-PIB) for visualizing fibrillar Aβ, has created new possibilities for early detection of brain impairments.
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However, FDR for these findings are of the order of 0.33, so they should be considered only as possible hypotheses to be further investigated.
We therefore considered only the possible association between aspects of the exposure assessment strategy and the heterogeneity in KL values and made no attempts to estimate the magnitude of the error in the CE directly.
A revision of the manuscript should in any case respond to the following points: a) The authors considered only one possible mode of action, in which one TOG domain of Stu2 binds to a tubulin subunit at the distal end of a microtubule while the other TOG domain binds to soluble tubulin.
However, perhaps differences would appear if we had considered only the highest possible point in each scale type, such as the proportion correct for ratings of 4, of 5, of 20, and of 100 for the four different scale types.
Our study considered only women; it is possible that our results may not be generalizable to men.
Consideration of these factors represents an advance in the application of the synoptic mass balance approach by placing error bars on estimates of constituent load and by allowing all sources of uncertainty to be quantified in aggregate; previous applications of the approach have provided only point estimates of constituent load and considered only a subset of the possible errors.
For those studies where it was possible, we considered only peptides identified by multiple search engines (see Materials and methods).
Therefore, pulmonary vein indices should be considered only one of the several possible indices to identify 'true' Grade II diastolic dysfunction.
Due to the high number of possible predictors being considered, only species with over 10,000 individuals in the data set were used for parameterising the model.
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