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Nevertheless, it is worth reiterating that we have considered only methods based on the RR-BLUP model, two sample sizes for genotypes, two sample sizes for markers, phenotypic data generated according to an α-design, and a single outlying observation in the phenotypic dataset.
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Similarly, sensitivity was also dominated by FIRMA, KLAS and ARH while considering only methods with non-zero specificity values.
Fourth, our assessment considered only the traditional methods commonly used in genetic diversity analysis, not those maximum likelihood or Bayesian methods recently developed for population genetic inferences from NGS data (see Nielsen et al. 2011).
This latter source was considered only if the method to produce the documents was described and potential conflicts of interests disclosed.
Not all methods provided a quantitative estimate of validity and most methods considered only the positive predictive value of a set of diagnostic codes in a highly selected group of cases.
The report based on the application of the EF method, described the different proportions of the area covered by each Marsh-Oberhuber grade, while the MO method considered only the worst one.
Lastly, we considered only the most commonly used methods of analysis which are readily available in current statistical software.
In the third model, we excluded all cases judged incident because of reported signs or symptoms of ARS (incidence definition 3 for the HIV notifications in Methods) and considered only the notifications with a previous negative HIV test.
Of the two methods using ML in coalescent process (the first two lines in Table 1), Wooding and Rogers' method (2002) considered only one population.
Our approach is to consider only heuristic methods here with the exception of Velicer's Partial Correlation test, which is a statistical method that does not require distributional assumptions nor is it computationally intensive.
Therefore, most of the studies in the literature consider only image-dependent methods, which strive to achieve a better balance between computational efficiency and visual quality of the quantization output.
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