If 16 or more objective responses were observed, the regimen would be considered worthy of additional evaluation in this disease.
For orphan drugs, market authorisation is considered proof of additional benefit by German regulations [§35a (1) German Social Code Book V], but only up to an annual revenue of 50 million Euros.
It is now established that steroid hormone or oestrogen receptor alpha (ERα) input, a fundamental driver for the growth of many breast cancers, should not be considered independent of additional signalling networks.
In addition, CDC officials are in the early stages of considering studies of additional air, water, and soil pollutants and utilizing other environmental data, Honein says.
California, ranked last among the states in per capita support for the arts, is considering $2 billion of additional cuts to K-12 education.
Future development will focus on enabling deposit of reviewed materials into other data archives and repositories and consider integration of additional capabilities that researchers find useful, such as reproducible research tools, virtual computing environments, and journal publication workflows.
A number of European utilities in Switzerland, Germany and the Netherlands are considering implementation of additional technologies to enhance the removal of emerging compounds in wastewater effluents such as advanced oxidation or activated carbon treatment.
Of course, such cost considerations can easily be included in the current framework, but as all costs where hypothetical we did not consider this of additional value, since these costs are typically not directly related to pharmacological action.
Thus while CBS was being seen as holding great potential, there was reluctance to consider allocation of additional resources: "There are many expectations from CBS but no resources committed to it".
By constraining the OD of the multi-pipe loop assembly to 75%% of the bore diameter, the study considered the benefit of additional loops.
