For MALDI-TOF analysis, we adapted the score values proposed by Sengh et al.: an isolate was considered correctly identified by MALDI-TOF when ≥2/4 spectra had a score ≥1.9 or 4/4 had a score ≥1.2.
Full comparisons between probes selected by CANDID, STRING, Random Forests, and fitSNPs are shown in Tables 1 and 2. We considered genes identified by more than one strategy to have the greatest potential for a role in BAV.
To extend the heart proteome coverage to lower abundance and shorter proteins [19], we also considered proteins identified by a single unique peptide as described in the methods section.
41 We considered participants identified by either method or taking antidepressants to be cases of depression.
To avoid underestimating the age of LCRs we also considered LCRs identified by SEG using more relaxed parameters (window = 15, K1 = 1.9 and K2 = 2.3) in the definition of a LCR's phylogenetic breadth.
The fit for persons showed that, for 84.23 % of individuals (collectively considering mismatches identified by infit and outfit MNSQ), the application of RSM to all items of the CD-RISC could conveniently explain response patterns.
Pharmacoeconomic analyses, including those that consider risks identified by the Women's Health Initiative, generally support the cost-effectiveness of hormonal therapy for menopause-associated vasomotor symptoms, which have been the mainstay for the management of these symptoms for more than 50 years.
Out of the 14 222 genes expressed in SAGE libraries from total testis, adult testis somatic cells and 7 somatic tissues (brain, eye, heart, liver, kidney, limbs and adipose tissue) (see Additional file 4) we considered only genes identified by corresponding tag count > 1.
Each exon was treated as a point of measure for the performance calculation with true positives (TPs) considered those exons identified by both ASCAT and ADTEx as gains/losses and false positives (FPs) considered those exons predicted by ADTEx as gains/losses and copy neutral by ASCAT.
For those studies where it was possible, we considered only peptides identified by multiple search engines (see Materials and methods).
