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In the indications of the Japanese Society for Cancer of the Colon and Rectum Guidelines for the Treatment of Colorectal Cancer, surgical treatment is indicated for recurrent CRC limited to one organ and considered for recurrence in two or more organs, if the lesions are resectable [8].
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Radiotherapy may be considered for patients with tumor recurrence.
Given the high number of cells resulting from the original 2 × 2 × 4 × 2 design (see "Statistical analysis"), only two categories were considered for the headache familial recurrence variable, that is "absent" and "double" (both in parents and grandparents).
There are numerous technologies that must be considered for management of local-regional recurrence and peritoneal metastases.
Pre-natal genetic testing should be considered for such families, as the recurrence risk may be as high as 50% upon maternal transmission.
MiRNA modulation (up/down) was used, and data from the first clinical evaluation until recurrence were considered for the non-parametric estimation of disease-free survival using the Kaplan-Meier method.
Patients with recurrence were promptly considered for either intra-vesical therapy or radical salvage cystectomy depending on the nature of the local recurrence.
Excision alone without RT may occasionally be considered for patients at low risk of recurrence.
Patients with such a high risk of recurrence could be considered for post-operative adjuvant therapy at this point whilst others would be suitable for a watchful waiting approach.
Additional tumours that develop during follow-up, including new tumours in the post-resection liver remnant or local recurrence, should be considered for ablation based upon anatomical and size criteria.
Long-standing preventative antiviral therapy could be considered for such patients who present with recurrences of intraocular inflammation.
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