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The Caterpillar concept has been chosen to be considered for further development.
Panel members were then charged with the identification of specific research proposals that could be considered for further development.
Because the newly discovered inhibitors are structurally diverse and reveal a significant potency with IC50 values lower than 50 μM, all of them can be considered for further development by structure activity relationship studies.
Because the newly discovered inhibitors are structurally diverse and reveal a significant potency with IC50 values lower than 50 μM, all of them can be considered for further development by structure activity relationship studies or de novo design methods.
Because the newly identified inhibitors are structurally diverse and reveal a significant potency with IC50 values ranging from 10 to 50 μM, all of them can be considered for further development by structure activity relationship or de novo design methods.
Among the most potent formulations tested, a simple mixture of the vaccine with a microfluidized dispersion of DC-Chol in an aqueous buffer is being considered for further development to produce an improved influenza vaccine.
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Thus, exosomes must be considered for further developments in understanding and treating vascular dysfunction in sepsis.
In summary, this study shows that glycoconjugates based on delipidated or partially delipidated LPS from H. pylori 26695 HP0826::Kan mutant induce broadly cross-reactive functional antibodies in immunized animals and should be considered for further vaccine development and testing.
Ideally, AO drugs targeting specific human dystrophin exon should be selected first in cell culture systems representing the targeted cells in human and the efficacy of the selected AOs will then be validated in vivo in animal models before the selected AOs are considered for further drug development including expensive toxicology and pharmacology tests.
We propose that approved and clinical stage immunomodulators in combination with standard of care neuraminidase inhibitors should be considered for further preclinical development with currently circulating strains.
These data, and that from other studies in a variety of major tumour types, led to the conclusion that amonafide should not be considered for further clinical development.
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