The outcome of this quality check (where 1 out of a sample of 20 was found to have been missed by the initial electronic search) was considered a reasonable underestimation (5%) by this search method, given the challenge presented by the absence of a unique patient identifier.
There are reasons why this average might be considered an overestimation or underestimation.
Notably, such a difference could also be considered as an underestimation; indeed, we already know that lowering the dose of interferon can lead to a reduction in side effects experienced by patients receiving the bevacizumab interferon combination, whereas efficacy seems to be maintained (Melichar et al, 2008), therefore potentially leading to further savings.
19 The largest FAP registries have reported a life time risk of 1 2%, 19, 20 but some consider this an underestimation.
However, for this model, both the over- and underestimation for the daphnids was within a factor of two, which could be considered a fairly good agreement.
This week, a United Nations official reported more than 1,100 cases of sexual violence last year in Somalia, a figure that the United Nations considers alarming but an underestimation.
However, this calculation might be an underestimation considering the unfinished character of the Physcomitrella genome sequence.
This number is likely to be an underestimation considering that five of the 77 OR genes taken at random were overexpressed at birth.
Consequently, the estimates for body weight of Hypnomys based on skull and dental measurements should be considered as underestimations.
Using data from other places, and given what they consider "inevitable" underestimation of the disease in poor countries due to limited awareness of it and low autopsy rates, the Colchesters estimate that there are 150 cases of CJD a year in India.
