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We have added these considerations to the Discussion.
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We added these considerations to the revised Discussion.
Although we have limited data to distinguish between these potential models we have added consideration of them to the Discussion, including the idea that heterozygous regions could receive higher DSB numbers via feedback signaling.
Their origin needs to be addressed later, based on additional analytical and biological considerations, which we postpone to the discussion.
These considerations have been added to the Discussion.
A rigorous analysis of the exact physical meaning of T1 and T2 exceeds the scope of the present study, but qualitative considerations can be brought to the discussion.
Please edit the text to tone down the conclusion regarding the role of adipocyte precursor cell proliferation, and add to the Discussion explicit consideration that PDZ-RhoGEF may act on multiple cell types including precursor cells, mature adipocytes or other cell types to influence adipose tissue development and homeostasis.
Now, we have expanded our thoughts and moved it to the Discussion, subsection "Technical considerations and relation with recent studies".
To deduce reasonable considerations in the Discussion section, we here define "contaminant-subtracted NAPs (csNAPs)" as follows: csNAPs = "Proteins detected only in the nucleoid fraction" + "Proteins calculated to be relatively abundant in the nucleoid fraction".
We defer to the Discussion section a consideration of how such a strain might have arisen.
You might add more consideration in the Discussion to your manipulations relative to nature.
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