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We conclude from our example that there are at least two advantages to a decision-support approach that treats evaluation and planning as distinct but integrated phases: (1) the overall decision process is rendered conceptually simpler and (2) practical considerations of efficacy and feasibility of management actions can be easily accommodated.
The non-zero MWTP and ECV estimates reported above provide a monetary measure of the "clinical usability" of a drug – where clinical usability has to do with the mode of drug administration as separate from considerations of efficacy, safety and/or value-for-money.
To argue considerations of efficacy on a moral question misses the point.
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These findings should inform the design of trials involving novel therapies, suggesting that angina status and mortality be included as primary end points in the consideration of efficacy.
In current practice, consideration of efficacy (and principal modes of action) versus significant risk of adverse effects in often frail elderly patients, means that antipsychotics are used mainly where non-pharmacological methods have failed to control distressing psychotic or other neuropsychiatric symptoms or the safety of the patient or others is compromised.
Finally, considerations on efficacy studies of drugs administered through aerosol delivery are discussed.
For more than a decade, several novel endoluminal therapies were developed, clinically evaluated, put on the market and, for many of them, withdrawn due to economic considerations, lack of efficacy or complications.
For pragmatists, the individual's interpretations of reality are motivated and justified by considerations of their efficacy and utility in serving his interests and needs.
…pragmatists, the individual's interpretations of reality are motivated and justified by considerations of their efficacy and utility in serving his interests and needs.
The persistence of high microbial loop activity causing strong wintertime system net-heterotrophy is highly relevant to considerations of the efficacy of Southern Ocean iron enrichment to control the level of atmospheric CO2.
In the absence of any directly comparative trials, this article seeks to place the various considerations of their efficacy in perspective.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com