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Steric considerations discussed below and high pKa value of arginine argue that R1056 is unlikely to fulfill this role, suggesting Y1043 as the most plausible partner of H1061.
It is not clear whether the lack of strong associations is due to confounding factors (e.g., dietary exposure), to variability in the biologic measurements (including toxicokinetic considerations (discussed below), or to a relatively weak link between residential contamination and child exposures.
The urinary acidity changes observed in response to food substitution are particularly relevant to the considerations discussed below.
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These considerations are discussed below and summarised in Additional File 1, Table S1.
The technique has been initiated in recently commenced live-gene banking programs of Atlantic salmon in Norway and Canada (O'Reilly and Doyle 2007), but like any tool, it has disadvantages that merit consideration as well (discussed below).
One new question, associated with integration of patient perspectives in EBP, demonstrated satisfactory psychometric properties and should be included in the modified FT. With consideration of the limitations discussed below, educators and researchers are encouraged to use the 13-item version of the modified FT to evaluate PT EBP curricula and physical therapists' EBP knowledge and skills.
Apart from the ethical considerations, which are important and discussed below, this may represent serious issues with hydration.
The rationale for the approach is thus discussed below under Emerging Considerations.
As discussed below under "Future Considerations," ethanol fixation also has advantages for microdissection and clonality assays.
Several key interactions identified in our analysis are discussed below, although, due to space considerations, not all possible interactions are addressed.
(Tychism will be discussed below).
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