Consideration of that hypothesis' explanatory power might then help us to figure out, if perhaps only within certain bounds, what prior to assign to it, or what likelihood to assign to it on the given evidence.
Interpretation of G × E research requires careful consideration of the hypotheses tested, first recognising that presence of statistical interaction depends on – and may be induced by – the scale of measurement.
13 14 The guidance is to spend 25% of any allocated discussion time on consideration of the hypotheses set out above, and 75% of time on a thought experiment: "if these data were showing up problems in our practice what might they be and how might we investigate this and rectify these issues".
Back in 2002, we believed that it was a polymerase and presented several considerations in support of this hypothesis that now seems unlikely to be true considering all we know about the CRISPR-Cas systems.
In consideration of this issue, we advanced hypotheses about the impact of baseline drinking patterns on strategy use and the relationship of strategy use to drinking patterns over time.
Ethical and practical considerations preclude a direct testing of this hypothesis (that is, establishing whether or not there is an association between prenatal mitogens and breast stem cell quantities) in humans.
This point regarding consideration of alternative hypotheses was emphasized by a recent Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel review relating to PPARα (FIFRA SAP 2004) and is a key part of the U.S. EPA cancer guidelines (U.S. EPA 2005).
Although a social influence perspective guided the theoretical framework of this study, the a priori consideration of themes, hypotheses and theoretical applications, was suspended until all data were analyzed.
To assess the accuracy of this hypothesis, however, larger RCTs are necessary to support consideration of relative risks for more specific levels of severity of outcome.
