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The "one drug, one target, and one disease" model is partially contributing to the increased failures of clinical trials due to its lacking consideration of side effects or toxicities in the early stage of drug discovery and development.
We stress the importance of careful consideration of side effects when starting topiramate therapy in a child, and the need for parental counseling of side effects.
The decision to use raloxifene should be based on evaluation of fracture risk and on potential other benefits than fracture reduction along with consideration of side effects.
Although consideration of side effects (some are quite serious) remains very important, the major factor limiting the use of biologics is their exorbitant acquisition price.
It highlights the need to keep a broad differential in mind when encountering sudden onset blurry vision in the primary care clinic, the need for careful consideration of side effects when starting topiramate therapy in a child, and the need for parental counseling of side effects.
6 The National Institute for Health and Clinical Excellence recommends that the choice of an antidepressant should be guided by consideration of side effects and the patient's preferences but that normally a selective serotonin reuptake inhibitor in generic form should be chosen.
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More efforts in this direction and further validation in xenograft models, as well as considerations of side effects, could move us closer to testing the approach presented here in humans.
When administering opioids parenterally, the physicochemical compatibility with all other drugs needs to be taken into consideration, as well as the risk of side effects arising from the combination (standard, expert agreement).
Moreover, current data suggest that GalNAc-T3 is an ideal therapeutic target with minimum risk of side effects, a nontrivial consideration, as adverse reactions caused by anticancer agents are a serious issue in clinical management.
In addition, pharmacological effects can be terminated within 24 h of removal if necessitated by the presence of side effects or other clinical considerations.
Selectivity for each of the three subtypes is an important consideration in drug design in order to minimise the possibility of side effects.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com