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These findings should inform the design of trials involving novel therapies, suggesting that angina status and mortality be included as primary end points in the consideration of efficacy.
In current practice, consideration of efficacy (and principal modes of action) versus significant risk of adverse effects in often frail elderly patients, means that antipsychotics are used mainly where non-pharmacological methods have failed to control distressing psychotic or other neuropsychiatric symptoms or the safety of the patient or others is compromised.
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The non-zero MWTP and ECV estimates reported above provide a monetary measure of the "clinical usability" of a drug – where clinical usability has to do with the mode of drug administration as separate from considerations of efficacy, safety and/or value-for-money.
We conclude from our example that there are at least two advantages to a decision-support approach that treats evaluation and planning as distinct but integrated phases: (1) the overall decision process is rendered conceptually simpler and (2) practical considerations of efficacy and feasibility of management actions can be easily accommodated.
In some cases, justification for the mixture may depend only on a theoretical consideration of the efficacy of the individual components and rely on procedures such as the model presented in this paper.
Consideration of both efficacy and tolerability should always be prominent in the glaucoma patients' treatment.
Evaluating bariatric surgery in this context mandates consideration of surgical efficacy, costs, and benefits.
The intelligent use of specific antimalarial drugs will require careful consideration of TBD efficacy, effect size, and transmission intensity/EIR in targeted areas.
In clinical practice, there is still no conclusive evidence to prefer one technique over the other in consideration of their efficacy and side effects.
These surprising results relate not only to the consideration of rituximab efficacy in RA, but also illustrate a more complex interaction of RF, IgG, and complement than previously appreciated.
In consideration of drug efficacy and future clinical use, weekly injections are an attractive option; however, further examination is needed to determine the optimal duration of the BMP-7 injection therapy for the osteoarthritic knee, based on several additional in vivo studies.
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