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However, since Bagci's model did not take the p53 oscillation dynamics into consideration, it is difficult to be able to evaluate the relationship of the dynamic behavior of p53 with the apoptosis induction.
Taking these facts into consideration, it is difficult to eliminate diabetic nephropathy where the role of the metabolic syndrome is assessed.
As most of the studies did not take stool characteristics into consideration, it is difficult to compare the present study with other studies.
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It is important to note at this point that, while an attempt can be made to estimate the relative force of different muscles in the same animal from average geometrical/structural considerations, it is difficult to do so across monkeys.
Due to ethical considerations, it is difficult to deny any intervention or treatment to individuals in this high-risk population [ 17].
Owing to ethical considerations, it is difficult to perform an RHC in all patients with SSc, especially those who are at very low risk of having PAH.
Given these considerations, it is difficult to establish guidelines that would enable us to recommend applying the KS test as an MI diagnostic.
Given the above considerations, it is difficult to see how chromosomal translocations could ever take hold in any population and reach fixation unless they were directly associated with a phenotype endowed with a very significant selective advantage.
When profit is the driving force, welfare is a distant consideration – and it is difficult to think of an industry where the pursuit of profit is more of a priority.
Very small tumors do not always yield excess material for the study, and due to clinical considerations, at present it is difficult to sample cases that appear to be purely or primarily carcinoma in situ.
Purity, yield, speed and cost are important considerations in plasmid purification, but it is difficult to achieve all of these at the same time.
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