CSVD on the basis of atherosclerosis will accelerate the development of AD since cerebral hypoperfusion and reduced glucose uptake have been found very early in AD, 28, 29 in consideration that the regulation of cerebral blood flow plays an important role in the coordinated interaction of neurons, glia, and vascular cells.
The goal of the study presented herein consists in the further elucidation of the interplay of the transcription factor NFκB, in the reciprocal regulation with SIRT1, taking into consideration possible feedback mechanisms in the regulation of these two proteins.
RECs in all jurisdictions planning such trials should be aware that public policy considerations are becoming increasingly important in the regulation of research and are being reflected in law.
In consideration of the role of 51A RNA in the regulation of amyloid formation in the in vitro model, we tested whether its expression might contribute to AD generation in ex vivo human brain samples.
Most of the previous studies examined the role of a single gene in OA without taking into consideration the interaction of the genes participating in the regulation of balance between pro- and anti-inflammatory processes.
In consideration of the importance of intracellular Ca2+ in the regulation of the cardiac contraction cycle, and reports of altered [Ca2+]i homeostasis in diabetes [ 30- 32], we have determined whether TETA could exert its inotropic effects through modulation of myocellular [Ca2+]i.
Very little consideration, however, has been placed on the possibility of the divergence in the regulation of GR target genes based on alterations in the GR/promoter region interaction.
Thank you for sending your work entitled "The Role of Cdc42 and Gic1 in the Regulation of Septin Filament Formation and Dissociation" for consideration at eLife.
Thank you for sending your work entitled "The GTPase IFT27 participates in the regulation of anterograde and retrograde intraflagellar transport" for consideration at eLife.
In any case, these considerations do not concern those cases in which the regulation of the interaction does not consist in a direct removal/substitution of the region involved in the interaction (which can be a domain, a motif or an interface), e.g. when a sequence is inserted within a binding domain.
