Our findings suggest that inclusion of non-verbal memory measures will be an important consideration for future trials.
Whether sensitivity to depsipeptide may be compromised by prior exposure to chemotherapy in clinical settings remains an open possibility, supported by our data, which must be taken into consideration for future trials.
However, the risk of invasive disease not detected at stereotactic core biopsy is an important consideration for future trials of non-operative treatment for preinvasive disease, and underscores the importance of patient selection in the design of preoperative clinical trials in DCIS.
Considerations for future trial designs, registries, and analyses of existing data are highlighted to better guide clinicians toward the optimal management of this rapidly growing, high-risk group.
Although not statistically significant owing to the small number of patients, this result implies that resistance to capecitabine may adversely influence the efficacy of S-1, and it should be an eligibility consideration for future clinical trial design.
to improve the training for future trials.
28 Although we decided not to use non-standard actigraphy placements such as shoulder/waist for this study, this should be an important consideration for future similar trials.
We also reviewed current available data on PD-1/PD-L1 inhibitors as monotherapy or combined with EGFR-TKIs in NSCLC with EGFR activating mutations, and explored possible factors influence its efficacy, which would be important considerations for future clinical trial designs.
Our work both demonstrates and emphasizes the significant impact of EoE on overall health and well-being, rather than just a focus on specific gastrointestinal symptoms, and is an important consideration for future pediatric clinical trials of new medications for pediatric EoE.
It demonstrates the feasibility of conducting high-quality clinical trials in CRPS type 1 and provides considerations for designing future trials.
