Sentence examples for considerably upstream of from inspiring English sources

As PMX464 prevented TNF-α-and IL-1β-induced IKK andinity and, in general, IL-1β and TNF pathways vary considerably upstream of IKK, this would suggest that PMX464 acts in close proximity to IKK.

However, the inserts in the current study were located considerably further upstream of any known RIPK1 exon.

The injured capillaries are highly permeable vessels and their recruitment may considerably increase fluid and protein leak upstream of the obstruction.

Therefore the region of the mouse Spam1 locus derived from the ERV1 pol region is considerably larger than that annotated by RepeatMasker, extending approximately 700 bp upstream of the transcriptional start site.

Thus, it appears that the wiring upstream of Yap1 and downstream of Mst1/Mst2 has been diversified considerably in mammals compared with the Drosophila Hippo pathway.

These mRNAs often contain a 5'-UTR considerably longer than the average cellular 5'-UTR [13], [14], may contain AUG codons upstream of the initiation codon for the main open reading frame, and have complex secondary structures [15].

Supporting this hypothesis, inhibition of Akt and MAPKs considerably inhibited 5-FU-induced TS upregulation, although not completely, which obviously indicates that these molecules are upstream of TS in the 5-FU signaling cascade.

While crossing, face upstream and keep your pole upstream of you so that the current forces it into the stream bed.

The researchers studied a 100km river catchment in the New Forest, upstream of the town of Brockenhurst.

He came from the town of Quft, about seventy miles upstream of Abydos.

Fifteen families have had to leave their homes in Haydon Bridge, 10 miles upstream of Corbridge.