The involvement of chemokines in tumor-endothelial interactions and their effect on tumor cell mechanics during invasion are considerably less well understood, however.
One matter that makes it difficult to tackle this question is the fact that the non-motor loops that connect the basal ganglia with human prefrontal cortex are considerably less well understood than basal ganglia cortical motor loops.
The reaction of cyanoacrylates with latent print residue is considerably more complicated and less well understood.
By the early 20th century, Plas Mawr's historical significance was increasingly well understood, but the costs of maintaining the house grew considerably.
The biodynamic responses of the seated human body to whole-body vibration vary considerably between people, but the reasons for the variability are not well understood.
However, I feel that showing a multiple sequence alignment of the RNase H family highlighting the members used in this study as well as the positions that constitute the substrate and metal binding sites would considerably help understand that indeed this pre-organization comes about despite divergent binding-site sequences.
Hence, considerably less is understood about this lethal metastatic disease, as it is not commonly studied.
As a consequence, considerably less is understood about the later acquired genetic alterations that emerge in the context of the selection pressure of an androgen-deprived milieu [ 6].
Although much is known about the requirement of transcription factors at these cytokine-inducible promoters, considerably less is understood about the coordination of the histone modifying events that allow these promoters to switch from a semi-poised state to a fully open, transcription-accessible structure.
"Before they're done we'll understand considerably more about how the world overheated.
Such a system should be considerably easier to understand than the human brain, a structure with billions of neurons, 100,000 miles of biological wiring and 100 trillion synapses.
