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A recent study comparing FeLV vaccine efficacy challenged cats with a considerably smaller dose volume and titre and achieved persistent antigenaemia in seven of eight controls, as well as five of eight vaccinated cats at seven months of age [ 11].
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A dramatic improvement in the crosslinking response was observed for the decadiene polymers and consequently considerably smaller radiation doses were needed to obtain a certain degree of crosslinking.
Our dose of GTN is considerably smaller than the dose chosen in experiments that administered GTN as an i.p. bolus injection [38, 39] but is 2.5 fold higher than the dose selected by Offenhauser et al. [31]in a study that failed to induce Fos expression.
The 60-mg dose would correspond to an oral LD50 of around 0.8 mg/kg, a dose that is considerably smaller than the values determined for laboratory animals, which are ranging from 3.3 (mice) to more than 50 mg/kg (rats) (Hayes 1982).
In our study, although the dose of coolant was considerably smaller than those in the studies by Kämäräinen and colleagues and Virkkunen and colleagues, we observed a significant and clinically relevant pre-hospital decrease of TT.
However, the doses of n-3 fatty acids in the present review were considerably smaller compared with those previously reported suggesting caution may need to be applied when administering higher doses until further evidence is obtained.
Because of this reason, the effective doses of EGCG required for PD patients may be considerably smaller than what were used in the present study.
Furthermore the recording of drugs and doses would have resulted in groups that would have been considerably smaller with no added value given the overall sample size pursued.
Poisson regression estimates of 95% confidence intervals (CIs) were considerably smaller than the MC results, which allow for extra-Poisson uncertainties due to reconstructed doses and the background thyroid cancer incidence.
So the payoffs feel considerably smaller.
RAEDER: Certainly not bigger than 40 tons, probably considerably smaller.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com