Sentence examples for considerably reduced expression from inspiring English sources

In HT29 colorectal adenocarcinoma cells, inhibition of PI3K was accompanied by a considerably reduced expression level of beta-catenin [53].

We observed that Hdac1ATG1 morphants exhibited considerably reduced expression of these genes throughout the developing CNS at both 12 hpf and 27 hpf.

To circumvent this and to assess the role of PKCδ in the TsSP-induced monocyte modulation, we isolated and analysed monocytes from patients with extremely rare mutations in the PRKCD gene [ 21, 22] that either lack PKCδ or have a considerably reduced expression in monocytes-derived macrophages [ 36].

Attempts to determine whether SHP1 N-SH2 and C-SH2 domains played a role in the regulation of SHP1 activity in the context of THEMIS association were thwarted by considerably reduced expression levels of the corresponding mutants, likely due to the mutations affecting protein stability.

The skipped isoform has a frameshift relative to the wild-type mRNA that results in a premature stop codon, leading to considerably reduced IKAP expression [9], [10].

However, induction of transcription by GAL4 considerably reduced white expression, indicating that the eye enhancer was still sensitive to high level of transcription.

However, both naringenin and naringenin/ β-CD complex considerably reduced their mRNA expression to different extents.

The BAT-enriched factors type II iodothyronine deiodinase (DIO2) and peroxisome proliferator-activated receptor γ (PPARG) co-activator 1α (PPARGC1A) were also highly expressed at days −2 and 0, but displayed a faster and stepwise decrease in expression, being considerably reduced already at days 0.5 and 1 and poorly expressed after day 4.

Hepatic Ppl mRNA expression was considerably reduced in Fxr−/− mice (8-fold).

In contrast, the induction of the downstream S phase E2F target genes cyclin A and MCM7 was considerably reduced at both protein and mRNA expression levels in preadipocytes treated with BSO (Figure 5D F).

The RASSF1A promoter was found to be hypermethylated in nearly all parathyroid adenomas examined and RASSF1A gene expression levels were considerably reduced in adenomas compared to normal parathyroid tissue.