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Many of the considerably potent inhibitors of baker's yeast α-glucosidase possessed lower inhibitory activities against mammalian α-glucosidase and is suggested to be due to the difference of molecular recognition in the binding site of the enzyme [ 49, 50].
We classified BPA and its derivatives into the four groups, depending on their receptor binding affinity for ERR-γ : that is, group A, BPA and chemicals as potent as BPA; group B, chemicals considerably potent; group C, chemicals moderately potent; and group D, inactive chemicals.
When the benzene B-ring of 4-α-cumylphenol was substituted with either methyl or ethyl, the resulting 4- tert-butylphenol [HO-C6H4-C CH3 2-CH3] and 4- tert-amylphenol [HO-C6H4-C CH3 2-CH3]H3] were considerandy potent, with values of 26.1 nM and 33.2 nM, respectively (Table 2).
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In contrast, 2,6- and 3,5-DMA both induced cell death, but exhibited considerable variation in potency, in which the aminophenol metabolites were considerably more potent than the corresponding N-hydroxylamines.
With 304 horsepower and 273 pound-feet of torque, the bigger engine is considerably more potent than the base motor, which makes 270 horsepower and 223 pound-feet.
The chaparral fires are considerably more potent than the forest fires Wade Wells saw when he was an undergraduate at the University of Idaho or when he worked as a firefighter in the Pacific Northwest.
With 360 horsepower and 332 pound-feet of torque, the TT RS is considerably more potent than the original Audi TT, which was introduced in 1998 with a mere 222 horsepower and a 4-cylinder engine.
The Groovy ($14) looks like a benign limeade but is considerably more potent; it's made with shiso-infused vodka and yuzu juice and is topped with a shiso leaf, a member of the mint family that adds a nice lilt to the drink.
The clozapine metabolite, desmethylclozapine, was considerably more potent than the parent drug, whereas clozapine N-oxide was essentially inactive.
Ionophore-induced LTB4 release was potently inhibited by BRO addition (IC50: 8.6 μg∙mL− 1) whereas the effect on PGE2 release was considerably less potent (IC50: 70.0 μg∙mL− 1).
That's still considerably less potent than an estimate from Russia's defense minister Sergei Ivanov, who asserted yesterday that the blast equaled 5 to 15 kilotons of TNT.
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