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Third-generation AI (tgAI), including anastrozole, letrozole, and exemestane, have replaced aminoglutethimide in the treatment of postmenopausal patients with MBC because of their considerably lower toxicity.
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Considerably lower cellular toxicity of the studied complexes to primary human hepatocytes was identified and demonstrated by the values of IC50, which were approximately an order of magnitude higher in most cases than those representing the cytotoxicity to the human cancer cell lines (Table 1).
Thus reducing the availability of primary amines by converting them into substituted guanidinium moieties considerably lowered the toxicity of pDNA complexes.
However, the toxicity of PDBA was considerably lower than that of carboplatin and especially cisplatin.
Toxicity during the second cycle was considerably lower than during the first and only one patient required dose reduction.
These findings raise concerns as to the developmental toxicity since the active BPA dose is considerably lower than the reported concentrations in the serum of pregnant women in the U.S. (5.9 ng/ml) and in South Korea (2.7 ng/ml) [ 29, 30].
The drug concentrations employed in this assay showed no direct toxicity on macrophages, while they drastically reduced the association index at considerably lower doses than those required to interfere with promastigotes.
Al can bind to nucleoside triphosphates approximately 10 times better than Mg, and the rate of hydrolysis for Al-ATP or Al-GTP complexes is considerably lower than that for the physiological Mg complex (10 times slower), supporting the hypothesis that toxicity is a result of Al ions displacement of Mg ions from nucleoside di- or triphosphate complexes [ 57].
Now they have considerably lower estimates.
Their golf scores were considerably lower.
(Lunch prices are considerably lower).
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