Sentence examples for considerably lower binding from inspiring English sources

We show that such proteins can bind with the same high specificity as prefolded protein, but have a considerably lower binding free energy.

Thus, as a hormonal ligand, while E4 has considerably lower binding affinity for ERα than E2, it forms a complex with this receptor that binds to a key coactivator protein, SRC3, almost as well as does the complex with E2.

The mutations E77A, R159E, K161E and N191R slightly decreased the nucleotide binding affinity (Additional file 6) but it is unlikely that this caused the loss of oligomerisation because the G4-motif mutant, Irga6-D186N, with a considerably lower binding affinity for guanine nucleotides, oligomerised relatively efficiently in the presence of GTP (see below).

The binding energies of medium-size clusters vary rather smoothly with N, but they are in general considerably lower than the binding energies of bulk matter.

Nuclear AP-2 α levels and AP-2 DNA binding activities were considerably lower in prostate, colon, ovary and pancreatic cell lines than in breast cancer cells.

We examined the in vitro nucleosome occupancy and predicted occupancy for memory effect and transcriptionally responsive promoter sequences, and found that memory effect promoter sequences showed considerably lower values in the vicinity of Abf1 binding sites.

Consequently, AtCERK1 binds (GlcNAc 6 with a considerably lower affinity (kd = 44.8 µM; Liu et al., 2012) than the LysM1 LysM3 binding groove of Ecp6 (kd = 280 pM; Figure 7B).

However, the TR binding affinity of T4 is considerably lower than that for T3.

This number of Myc-binding sites is consistent with what was found in an earlier study that used DamID for assessing Myc binding [ 14], but it is considerably lower than the nearly 4,000 sites that were recently reported for a ChIPseq study of Drosophila Kc167 cells [ 27].

The existing data indicate that saliva levels can be considerably lower than blood levels of a pesticide, depending upon the degree of protein binding that may occur; thus, a very sensitive analytical technique is required.

Remarkably, changes in SHBG, corticosteroid binding globulin (CBG), angiotensinogen, triglycerides, or coagulation proteins were minimal and considerably lower than in the comparator group receiving a combination of EE and drospirenone.