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A friend growing up had a combination of prosthetic legs that replaced the limbs he'd been born without pretty admirably, using a combination of hydraulics and mechanical joints, but without any real smarts and so with considerably limitations (he drove using steering wheel-mounted controls rather than foot pedals, for instance).
It is important to note that equation (1) predicts the maximum possible rate of adaptation, but that low heritability, pleiotropy, environmental stochasticity around the changing optimum, or drift could reduce this prediction considerably (limitations of these types of models are reviewed more thoroughly in Bürger and Krall (2004)).
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Most of the phase III trials on AEDs in children have major methodological limitations that considerably limit meaningful conclusions about comparative efficacy between old and new molecules.
We have attempted to circumvent this limitation by restricting the analysis to HPV-positive-LSIL, but this considerably limited the power of our study.
Advent of massive parallel sequencing technology has considerably eased these limitations.
It was found that almost all the existing theoretical models significantly overpredict the effective diffusion coefficient by as much as 4 5 times; thus, underestimating the transport limitations considerably.
By using literature data on the in-diffusion of traces of radioactive cesium in an argillaceous rock (Opalinus clay) and a compacted bentonite (FEBEX bentonite), we have demonstrated that taking into account the mass-transfer limitations considerably improves the quality of the theoretical fit of the time evolution of radio-tracer concentration in the reservoir.
This "double jeopardy" suggests that both risk factors combined increased the risk of lower-body functional limitations considerably more than diabetes or adverse block face conditions alone [ 29].
The injury burden associated with housing will be estimated to be considerably larger when limitations can be addressed in the quality of the evidence, the range of exposures measured, and the scope of relevant details of injury circumstances currently recorded in surveillance systems.
However, the highly significant results (p-value < 0.00001) considerably overshadow the limitation.
The proposed framework has shown good results in forecasting innovation activities trigged by M&A deals; however, further research aimed at minimizing the above limitations can considerably extend functionality and accuracy of the proposed scheme of analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com