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Recent clinical studies performed in a large number of patients showed that colistin "forgotten" for several decades revived for the management of infections due to multidrug-resistant (MDR) Gram-negative bacteria (GNB) and had acceptable effectiveness and considerably less toxicity than that reported in older publications.
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A systematic review of the toxicity of polymyxin revealed that in the old literature, incidences of both toxicities were reported to be considerably high, while new evidence shows less toxicity than previously reported although the definition of nephrotoxicity was not standardised between the studies [30].
The polymersome VEGF complex showed a considerably higher binding affinity, transfection efficiency, and less toxicity because of the peptide-based polymer backbone.
Gastrointestinal toxicity (i.e., diarrhoea, nausea, and vomiting) was considerably less developed in this study, whereas the incidence of haematological toxicity was similar in both studies (Table 4).
The treatment of relapsed AML patients is considerably less successful, especially in the elderly, because the toxicity of standard induction chemotherapy is poorly tolerated in the older age group [ 1, 2].
The combination of carboplatin and docetaxel caused considerably less neurotoxicity than carboplatin-paclitaxel with grade ≥ 2 neurosensory toxicity in 11% versus 30% and grade ≥ 2 neuromotor toxicity in 3% versus 7% of patients.
Eupatorin had submicromolar toxicity in MDA-MB-468 cells (IC50 0.5 μM), whereas it was considerably less active in MCF-10A cells (IC50 50 μM).
Because the initial step in the turnover of naphthalene is critical to toxicity, these data would indicate that monkeys and humans would be considerably less susceptible to naphthalene exposure than rodents.
Pennsylvania is considerably less elastic.
Almost all make considerably less.
Otherwise, the starting salary is considerably less.
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