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That's still considerably less potent than an estimate from Russia's defense minister Sergei Ivanov, who asserted yesterday that the blast equaled 5 to 15 kilotons of TNT.
Incorporation of a conformationally more rigid 3-aroyloxy substituent onto the 6-methylsulfonylindole scaffold led to selective, but considerably less potent COX-2 inhibitors.
Ionophore-induced LTB4 release was potently inhibited by BRO addition (IC50: 8.6 μg∙mL− 1) whereas the effect on PGE2 release was considerably less potent (IC50: 70.0 μg∙mL− 1).
Interestingly, Ibrutinib, AVL-292, and CGI-1746 were all considerably less potent against these cell lines.
The only exception was the clone bearing the pfcarl S1076I mutation, to which KAF156 proved considerably less potent.
The OH-PCBs were considerably less potent inhibitors when assay tubes contained 1.0 μM 3-OH-BaP.
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RGS-GAIP was substantially less potent.
That's more than the $103 million spent in 2010 by the financial service industry, another potent lobbying force -- but considerably less than the $240 million spent by the pharmaceutical industry.
As for Jones, well, perhaps his delusions are less potent.
It is likely that the extent of sulfhydryl group modification in our system is considerably less than in [ 50] and [ 26], which used a potent alkylating agent (N-ethylmaleimide) and millimolar concentrations of HNE respectively.
Furthermore, with the exception of LPA5, the alkyl analogues of LPA are less potent agonists of the remaining LPA GPCR; however, 1-O-alkyl glycerophosphate is considerably more potent than LPA at PPARγ (Zhang et al., 2004; Tsukahara et al., 2006).
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