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It is becoming increasingly clear that the genetic control over most complex traits is due to a combination of common and rare variants, and that the rare variants contributing to these interactions exhibit considerably larger effect sizes than most common variants [52].
However, transcript levels are more dramatically modulated by TSA in the SUM149PT cells, whereas CG-1521 has a considerably larger effect on mRNA expression in SUM190PT cells.
One trial (Wahlstrom 2011) had a considerably larger effect size than the others, but we considered this trial to be of high risk of bias due to questions about analysis methods in the trial.
ANC coverage: four or more visits (Analysis 2.1) - one trial (Wahlstrom 2011) had a considerably larger effect size than the others, and we considered this trial to be of high risk of bias due to questions about analysis methods in the trial.
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In addition, a substituent at the N8-position has a considerably large effect on the ionization potential because this atom makes the second largest contribution to the HOMO.
Given these considerably large effect sizes, the underlying causative loci should be mappable in future integrative QTL studies, even with relatively small sample sizes.
Moreover, they used a temperature-independent grain size piezometer to estimate differential stress during natural deformation, although considerably large effects of temperature are theoretically predicted (De Bresser et al.2001; Shimizu2008,2012).
However, effect sizes derived from studies based on maternal rank were considerably larger than effect sizes based on direct measures of maternal condition at conception.
Other recent cohort studies have reported considerably larger estimated effect sizes than the expert mean judgment (e.g., Miller et al. 2007; Puett et al. 2009), suggesting that our approach is conservative.
The comparison between the results of Table 1 and Table 2 for the same set of assumptions shows that considerably larger mitigation effects would be achieved when combination of different interventions are considered.
In a meta-analysis of internet-based interventions for anxiety and depression, Spek et al. found that the effect of interventions with therapist support was considerably larger than the effect of interventions without a therapist [ 13].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com