Variables estimated by a clinical expert apparently do not considerably influence incremental costs.
Why? Partly it's a matter of increased media savviness – in recent years large research centres like Cern have become considerably cleverer at turning the often incremental nature of scientific progress into attention-grabbing events.
Moreover, incremental expenditures would be considerably lower than investments in many other well accepted social programs (e.g., airline and automobile safety) per life year gained [ 23].
Variability in both incremental costs and QALYs was considerably greater under the lifetime horizon, compared to the trial time horizon.
All studies but three were funded by the manufacturing company, and the median incremental cost-effectiveness ratio was considerably higher for independent than for sponsored analyses (62,000 euros vs 15,000 euros/QALY).
8, 28, 38 This estimate is considerably higher than even the highest estimated incremental cost of RxO abuse in the EU5 countries (€2,551 in Germany), although this difference may in part reflect higher costs of care in the US.
Doubling the number of hydraulic fractures per stage results in considerably greater gas injection requirements without proportionally larger incremental recovery factors.
The option for Type-I HARQ with chase combining is supported by some recent results [20 22], which demonstrate that Type-I HARQ may perform very close to Type-II HARQ (incremental redundancy--IR) with a considerably smaller computational complexity.
While estimates of life expectancy varied considerably with plausible changes in uncertain assumptions, the incremental gains associated with comparing different treatment strategies within a single cohort varied far less.
Bakanae disease, caused by seed-borne Fusarium species, mainly F. fujikuroi, is a rice disease whose importance is considerably increasing in several rice growing countries, leading to incremental production losses.
