Supernumerary teats are a problem in goat breeding as they can considerably impede machine milking efficiency, leading to increased milking time and injury.
While limited in length, these increases in local curvature considerably impede unfolding at a low temperature and enhance stability in spite of the relatively high bending energy of the looped structure.
In contrast, irrespective to the combination of mouse strains, M. tuberculosis infection is always controlled by many genetic loci [11], [35], and multiple intercrosses between the resulting regulatory pathways considerably impede simple interpretations.
However, the C incorporation into UTP was slightly hindered, and that into dCTP and dATP was considerably impeded.
The presence of the intact BBB in such regions of the tumors can considerably impede drug delivery to these regions [ 13– 15].
This study quantitatively demonstrates that naturally abundant quasi-specific sites on DNA can considerably impede the target search processes of sequence-specific DNA-binding proteins.
When Atg7 (an essential gene for autophagy) KO MEFs (Komatsu et al. 2005) were used as a positive control, the clearance of depolarized mitochondria was considerably impeded after CCCP treatment for 24 h [ Fig. 6A and (Matsuda et al. 2010)].
Thus, while mutations in hirudin-like region 659−663 of factor Va have a differential effect on the rate of cleavage at Arg, deletion or substitutions of amino acid residues within the same region have a similar effect on prothrombinase, namely, considerably impeding the acceleration of the rate of cleavage at Arg of meizothrombin attributed to the interaction of factor Va with factor Xa (3, 40).
In contrast, the agonist-bound conformation of the human corticotropin-releasing factor receptor is considerably less stable, impeding the formation of good quality crystals for structure determination.
In contrast, the outer membrane of Gram-negative bacteria with a bilamellar membrane covering the only 3 nm thick peptidoglycan layer is able to impede photosensitizer diffusion considerably, especially the negatively charged or neutral photosensitizers.
