Given that CNV-formation rate is considerably higher than the mutation rate for single base pairs [27], it is advisable to create population-specific priors to account for varying degrees of genetic diversity.
However, we found a considerably higher frequency of mutations in exon 19 than in exon 21.
We suggest that the involvement of TLSPs in processing of meiotic DSBs could be responsible for the considerably higher frequency of mutations reported during meiosis compared with that found in mitotically dividing cells, and therefore may contribute to faster evolutionary divergence than previously assumed.
As the hazard hbo(x) is considerably higher for individuals carrying a mutation than for individuals without a mutation (up to 61 times higher), the risk for carriers of developing a sporadic cancer (i.e. not associated with a mutation) can be considered negligible.
Comparing the three different evaluation schemes, all four methods achieved a considerably higher prediction performance when the unseen-mutation evaluation was used (Table 1).
The mutation rate for pepsin homologues amongst bacteria must therefore be considerably higher than eukaryote members of the family, and this rapid mutation rate might explain their placing near the root of the phylogenetic tree.
The fraction of immunogenic mutations, in contrast, is considerably higher.
The frequency of typical mutations, such as albino phenotype, was considerably higher in our library than in previously reported soybean mutant populations [ 40, 41].
Recently, Schneider et al. [ 25] have described that the co-occurrence of R75Q mutation in CFTR and variants of SPINK1 was considerably higher in patients with ICP, compared with the control group (8.75 % vs. 0.38 %).
Recent data show that BRCA2 appears to be a significant driver in MBC, with a considerably higher penetrance within male BRCA2 carriers compared with males in BRCAX families and BRCA1 male mutation carriers [ 1].
