Sentence examples for considerably higher doses from inspiring English sources

This is particularly an issue for preclinical studies like toxicological trials, in which considerably higher doses and volumes are being administered compared to clinical studies.

Considerably higher doses of artesunate are needed to produce neurotoxicity in animals.

The lowering of TSH concentration at considerably higher doses of thyroxine suggested there was some absorption, probably from the large bowel [ 12].

Adverse events (AEs) rarely occur in conventional radiotherapy using considerably higher doses (e.g. 30 x 2 Gy and higher versus 2 Gy in this trial) [ 43].

These AEs rarely occur in conventional radiotherapy using considerably higher doses (neoadjuvant 5 × 5 Gy for rectal or gastric cancer, 54 Gy in pancreatic cancer) [ 17, 18].

P3 More positively, others described being referred by their GP to specialist drug and alcohol services, and these were associated most often with those taking considerably higher doses of medicine and occurred also from self-referrals and court orders.

Location C had considerably higher dose in preterm children (90.5 ± 4.6 for preterm and 76.9 ± 3.5 for term).

In collagen- and adjuvant-induced arthritis, the combination had an equipotent anti-inflammatory action compared with a considerably higher dose of prednisolone alone.

However, 15 months post IR a drastic demyelination was observed (46% decrease compared with controls), albeit after a considerably higher dose (25 Gy).

In contrast, the present data show that a considerably higher dose of methylprednisolone (500 μg, equivalent to about 1500 μg/kg) despite completely suppressing corticosterone secretion failed to block the response to exogenous CRH.

Given that a considerably higher dose of oxaliplatin compared with cisplatin can be given in IPC, the platinum of choice for IPC in PMP to achieve maximum effect is suggested to be oxaliplatin.