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Interestingly, the mutants were able to grow and to produce macedocin at considerably higher concentrations of NaCl compared to the wild-type (up to 4.0% w/v).
In contrast, ovarian A2780 cells could be selected for resistance to considerably higher concentrations of docetaxel.
Alternative explanations of why S. wertheimae galls contain considerably higher concentrations of well-known defence compounds than their host plants are possible.
Therefore, when tumor cells metastasize to sentinel lymph nodes, they are liable to be subjected to considerably higher concentrations of SDF-1 than those staying in the primary site of breast tissue, which might stimulate chemokinesis of tumor cells.
Only 2% of all samples had p,p′-DDT concentrations above LOD; however, this could not fully be explained by the instrument performance as previous studies from the same areas have reported considerably higher concentrations of p,p′-DDT than the LOD in the current study.
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BE induces cell death more rapidly as compared to BetA, but to achieve similar amounts of cell death a considerably higher concentration of BE is needed.
As shown in Fig. S1, NSC321206 effectively eliminated all MDA-MB-231 cells at a concentration of 1 µM (GI50 value of 0.4 µM), while the non-malignant breast epithelial cell line (MCF10A) were only partially affected, at a considerably higher concentration of this compound.
The considerably higher concentration of L-glutamic andd and lower concentration of L-glutamine reported by GC-MS relative to NMR and DFI MS/MS may be due to the hydrolysis of L-glutamine to L-glutamic acid [92] or the conversion of L-glutamine to pyroglutamic during derivatization [93].
The authors demonstrated considerably higher concentration of peptides but did not measure BCMs, although they may have been present in this cheese.
In fact, such carriers act as drug reservoirs and are capable of providing considerably higher concentration of the drug outside and inside the malignant cells especially after being uptaken, since higher concentration correlates with earlier and more rapid apoptosis induction [ 4, 5].
The authors suggested that pasteurization of milk results in a decrease in peptide content during ripening, with considerably higher concentration of peptides being reported in cheese made from raw milk than from pasteurized milk; however, the actual peptides produced were not identified.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com