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However, in vitro affinity studies showed that losartan has considerably higher affinity.
DNA-binding assays revealed that both the polymerase and ligase domains bind DNA in vitro, the latter with considerably higher affinity.
However, IR-A shows considerably higher affinity for IGF-1 and particularly for IGF-2 than IR-B [16], and has been implicated together with the IGF1R in malignant transformation [17], [18].
The full-length intact protein domains demonstrated considerably higher affinity compared to the experiments with the isolated peptides, presumably because of cooperative binding at multiple sites.
Moreover, we also observed binding of MDk/W452(H5N8) to α2,6′-SLN-PAA-biotin probes, which have been proposed to be authentic analogs for influenza virus receptors in mammalian hosts, with considerably higher affinity than that displayed by the HPAI A(H5N1) viruses used in this study.
Rat and human Mrp3/MRP3 have been demonstrated in heterologous expression systems to mediate ATP-dependent bile salt transport (Hirohashi et al. 2000; Zeng et al. 2000; Akita et al. 2002), whereby the human system has a considerably higher affinity for bile salts than the rat system.
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In contrast, SPPV14 interacts with several BH3-only proteins (Bim, Bid, Bmf, Hrk and Puma) as well as Bak and Bax at considerably higher affinities (Table 1).
The polymersome VEGF complex showed a considerably higher binding affinity, transfection efficiency, and less toxicity because of the peptide-based polymer backbone.
They found that the ubiquicidin peptide fragments UBI 18 35, UBI 31 38, UBI 22 35, and UBI 29 41 showed considerably higher binding affinities for the bacterial cells than they did for the human leukocytes.
In the presence of saturating SecYEG, the stimulation reached the same level as the control; however, the apparent affinity was considerably higher, ~500-fold.
The apparent photosynthetic affinity of diatoms for inorganic carbon (Ci) is considerably higher than expected based on the affinity of their Rubisco for CO2 [5].
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