Sentence examples for considerably elevated and from inspiring English sources

Similarly, serum levels of IL-6 in TNF transgenic animals (TNF-knockout mice) are considerably elevated, and these animals have progressive and aggressively destructive arthritis [ 9].

Importantly, when faced with a patient who has received prophylaxis, a clinician must consider that such a patient's risk for a resistant candidemia may be considerably elevated and factor this information into his/her empiric treatment decisions.

In general, patients with ESRD appear to exhibit normal or high concentrations of IGF-I and considerably elevated concentrations of IGFBP-I and IGFBP-III, which increase with declining renal function, 13 demonstrating that the GH IGF-I axis is affected on several levels.

Incomplete seating on the bone may result in considerably elevated implant-bone micromotion and bone strains, thereby increasing the risk for TAR failure.

Accordingly, these participants have a considerably elevated risk of morbidity and mortality.

In addition, both RT-PCR and immunoblotting showed that killing the parasite with BW720c considerably elevated the level of TLR4 mRNA and protein (Fig 5B and C).

Thus, if the level of serum antibodies was normalized to the number of B lymphocytes present in the spleen, i.e. cells with the potential to secrete pathogen specific antibody, the perinatal lethal mice had considerably elevated levels of circulating IgM and IgG compared to wild type, Tg, and KO mice, consistent with an ongoing infection (Fig. 7C, D).

These discrepancies of in vivo and in vitro data presumably reflect the requirement of considerably elevated local NOD1 CARD concentrations and challenge the relevance of CARD-mediated homodimer formation in vivo, in particular as endogenous NOD1 levels are thought to be very low.

Iron deficiency leads to increased erythroblast numbers and increased TfR expression and thus to considerably elevated sTfR levels.

Whereas bone mineral density (BMD) and OCN were significantly decreased in TH mice, RANKL, IL-6, and IL-17 expression and osteoclast activity were considerably elevated.

HFD-fed rats exhibited considerably elevated levels of serum ALT, AST and ALP.