Sentence examples for considerably downstream of from inspiring English sources

For example, sequences considerably downstream of the TSS may be part of the functional promoter or of transcription-elongation regulatory elements such that local methylation could alter gene expression levels.

Any novel therapeutic strategies will thus have to be very selective for the disease pathways they are to target and, as a result, are more likely to involve critical regulators of the HIF pathway unique to that disease condition and considerably downstream of the global regulator itself.

A second crossover is considerably downstream: in two of the recombinants, the other crossover occurred between markers at mt3124 and 3184, and between markers at mt3379 and 3445.

Metal contamination is considerably higher downstream of Godolphin (total zinc ∽570 μg/L; total copper 36 μg/L; total arsenic ∽11 μg/L) compared to the upstream section of the catchment (total zinc ∽36 μg/L; total copper ∽6 μg/L; total arsenic ∽3 μg/L).

Secondly, a minimised air demand would considerably reduce negative effects downstream of the turbine casing, such as a reduced transport capacity and corrosion.

To our surprise, a recent report showed that expression of Myc and Sox2 downstream of IRES is considerably higher than that of Oct4 and Klf4 upstream of IRES [36], which may be explained by a growth advantage to fibroblasts conferred by high-level Myc expression and thus is selected for.

When buoyancy was less significant, bubbles dispersed uniformly in the high-shear zone just downstream of the impeller, with considerably better mixing than without the impeller.

Compared to our previous constructs, protein expression was considerably enhanced by insertion of synthetic introns downstream of the human cytomegalovirus immediate-early promoter within the 5′-nontranslated region of the transgenes.

These charts indicate that potential heads along the entire floor and the hydraulic exit gradient downstream of the structure are considerably decreased by the provision of two filters even with very small length.

However, unlike nucleosome-depleted regions that are generally localized to core promoters and enhancers, H1 displacement is considerably more extensive, extending significantly upstream and downstream of the transcription start site (TSS) [ 7– 9].

When using a synthetic turbulence generator, the statistics obtained downstream of the inlet might deviate considerably from the intended values.