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A second crossover is considerably downstream: in two of the recombinants, the other crossover occurred between markers at mt3124 and 3184, and between markers at mt3379 and 3445.
For example, sequences considerably downstream of the TSS may be part of the functional promoter or of transcription-elongation regulatory elements such that local methylation could alter gene expression levels.
Any novel therapeutic strategies will thus have to be very selective for the disease pathways they are to target and, as a result, are more likely to involve critical regulators of the HIF pathway unique to that disease condition and considerably downstream of the global regulator itself.
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Metal contamination is considerably higher downstream of Godolphin (total zinc ∽570 μg/L; total copper 36 μg/L; total arsenic ∽11 μg/L) compared to the upstream section of the catchment (total zinc ∽36 μg/L; total copper ∽6 μg/L; total arsenic ∽3 μg/L).
In other broadband mediums, the upstream speed can be considerably slower than downstream.
These can do considerable damage downstream.
Secondly, a minimised air demand would considerably reduce negative effects downstream of the turbine casing, such as a reduced transport capacity and corrosion.
Similarly, the standard ellipse area (SEA) size was greatest at upstream and decreased considerably at midstream and downstream.
In this study, as discussed previously, the changes in SEA are mainly determined by CR which decreased considerably from upstream to downstream.
In addition to the considerably shortened expression time, the downstream purification process is significantly faster with the application of affinity purification column.
Furthermore, downstream analysis is considerably simpler and less time-consuming.
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